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Inventi Impact: NDDS

Articles

  • Inventi:pndds/24864/18
    Folate-Functionalized Mesoporous Silica Nanoparticles as a Liver Tumor-Targeted Drug Delivery\nSystem to Improve the Antitumor Effect of Paclitaxel
    01-Jan-1970 Research 2018 : January - March
    Xiaoyan Xu, Chao Wu, Andi Bai, Xuan Liu, Huiling Lv, Ying Liu

    The aim of this study was to prepare and characterize an innovative hepatocellular carcinoma-targeted therapeutic drug\ndelivery system based on folate-PEG-mesoporous silica nanoparticles (FA-PEG-MSNs) loaded with paclitaxel (PTX). In vitro cell\nexperiments and an in vivo antitumor efficacy study demonstrated that FA-PEG-MSNs-PTX produced significantly higher tumor\ninhibition compared with pure PTX and mesoporous silica nanoparticles loaded with paclitaxel (MSNs-PTX). The biodistribution\ninvestigation of PTX in nude mice revealed that the FA-PEG-MSNs-PTX could accumulate in tumors. Folic acid functionalized\nMSNs resulted in a good targeting effect, confirming that FA-PEG-MSNs-PTX is a promising tumor-targeted drug delivery system\nfor liver cancer chemotherapy.

    How to Cite this Article
    CC Compliant Citation: Xiaoyan Xu, Chao Wu, Andi Bai, Xuan Liu,\nHuiling Lv, and Ying Liu, â??Folate-Functionalized Mesoporous Silica\nNanoparticles as a Liver Tumor-Targeted Drug Delivery System to\nImprove the Antitumor Effect of Paclitaxel,â? Journal of\nNanomaterials, vol. 2017, Article ID 2069685, 13 pages, 2017.\ndoi:10.1155/2017/2069685, https://creativecommons.org/\nlicenses/by/4.0/.
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